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ORIGINAL ARTICLE
Year : 2021  |  Volume : 6  |  Issue : 2  |  Page : 146-149

Evaluation of prevalence of weak D antigen among rhesus-negative patients in tertiary care hospitals in Bangladesh: A multicenter study


1 Department of Transfusion Medicine, Evercare Hospital, Dhaka, Bangladesh
2 Department of Transfusion Medicine, Square Hospitals Limited, Dhaka, Bangladesh
3 Department of Transfusion Medicine, Asgar Ali Hospital, Dhaka, Bangladesh
4 Department of Transfusion Medicine and Additional Registrar, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
5 Department of Hematology and Stem Cell Transplant, Evercare Hospital, Dhaka, Bangladesh

Correspondence Address:
Dr. Tamanna Afroz
Department of Transfusion Medicine, Evercare Hospital, Dhaka
Bangladesh
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/gjtm.gjtm_118_20

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Background and Objectives: In 1939, D antigen was discovered which is believed to be the most immunogenic antigen in Rhesus (Rh) blood group system. There are some D variants such as weak D, partial D, and DEL due to gene polymorphism. These variants can cause RhD-positive person to behave like RhD negative which could result in alloimmunization. Clinically weak D antigen is very important due to its strong immunogenicity in spite of its low frequency. Hence, we need to know the prevalence of weak D variants in the community. The purpose of this study is to find out weak D prevalence among the Bangladeshi population. Methods: It is a retrospective study done over the last 5 years, from January 2015 to December 2019, at the department of transfusion medicine of three tertiary care hospitals in Bangladesh. A total of 177,702 patients were enrolled in the study. Blood samples that were negative for RhD were tested for weak D by indirect antiglobulin test according to institutional protocol. Results: Out of 177,702 patients, 7359 (4.1%) were found to be RhD negative and among those, 14 (0.19%) were weak D antigen positive. Conclusion: Weak D antigen is prevalent in Bangladesh and every RhD-negative individual should be checked for the presence of weak D to prevent RhD alloimmunization.


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