Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online:381
  • Home
  • Print this page
  • Email this page
Year : 2021  |  Volume : 6  |  Issue : 2  |  Page : 146-149

Evaluation of prevalence of weak D antigen among rhesus-negative patients in tertiary care hospitals in Bangladesh: A multicenter study

1 Department of Transfusion Medicine, Evercare Hospital, Dhaka, Bangladesh
2 Department of Transfusion Medicine, Square Hospitals Limited, Dhaka, Bangladesh
3 Department of Transfusion Medicine, Asgar Ali Hospital, Dhaka, Bangladesh
4 Department of Transfusion Medicine and Additional Registrar, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
5 Department of Hematology and Stem Cell Transplant, Evercare Hospital, Dhaka, Bangladesh

Correspondence Address:
Dr. Tamanna Afroz
Department of Transfusion Medicine, Evercare Hospital, Dhaka
Login to access the Email id

Source of Support: None, Conflict of Interest: None

DOI: 10.4103/gjtm.gjtm_118_20

Rights and Permissions

Background and Objectives: In 1939, D antigen was discovered which is believed to be the most immunogenic antigen in Rhesus (Rh) blood group system. There are some D variants such as weak D, partial D, and DEL due to gene polymorphism. These variants can cause RhD-positive person to behave like RhD negative which could result in alloimmunization. Clinically weak D antigen is very important due to its strong immunogenicity in spite of its low frequency. Hence, we need to know the prevalence of weak D variants in the community. The purpose of this study is to find out weak D prevalence among the Bangladeshi population. Methods: It is a retrospective study done over the last 5 years, from January 2015 to December 2019, at the department of transfusion medicine of three tertiary care hospitals in Bangladesh. A total of 177,702 patients were enrolled in the study. Blood samples that were negative for RhD were tested for weak D by indirect antiglobulin test according to institutional protocol. Results: Out of 177,702 patients, 7359 (4.1%) were found to be RhD negative and among those, 14 (0.19%) were weak D antigen positive. Conclusion: Weak D antigen is prevalent in Bangladesh and every RhD-negative individual should be checked for the presence of weak D to prevent RhD alloimmunization.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded42    
    Comments [Add]    

Recommend this journal