Home About us Editorial board Ahead of print Current issue Search Archives Submit article Instructions Subscribe Contacts Login 
  • Users Online:160
  • Home
  • Print this page
  • Email this page
CASE REPORT
Year : 2022  |  Volume : 7  |  Issue : 1  |  Page : 99-102

Rare Anti-Cw antibody: Two case reports with review of literature


Department of Immunohematology and Blood Transfusion, Sri Balaji Action Medical Institute, New Delhi, India

Correspondence Address:
Dr. Sadhana Mangwana
Department of Immunohematology and Blood Transfusion, Sri Balaji Action Medical Institute, New Delhi
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/gjtm.gjtm_92_21

Rights and Permissions

Introduction: Anti-Cw is a low-frequency antibody against Cw (Rh8) antigen, a low incidence antigen of the Rh system. Anti-Cw antibody may cause mild to moderate hemolytic disease of the fetus and newborn (HDFN) and mild to severe immediate or delayed hemolytic transfusion reactions (HTR). The antigenic frequency of Cw in the Indian population is 1.25%. Two cases of Anti-Cw antibody are being reported which were detected during routine antibody screening, one an oncology patient and the other a healthy blood donor. Case 1: A 30-year-old male, known case of acute myeloid leukemia, with previous history of induction chemotherapy and blood transfusion was admitted for further management and chemotherapy. When three cell antibody screening was performed using an automated platform, the screen was positive with +2 reactions. Antibody identification using 14 cells suggested the presence of an Anti-Cw antibody. On further testing, the patient red blood cell (RBCs) were negative for Cw antigen. Case 2: A 20-year-old male, first-time, voluntary blood donor, with no history of blood transfusion donated whole blood. On performing three cell antibody screening using automated platform, screen was found to be positive with +3 reactions. Antibody identification performed using 14 cell panel suggested the presence of Anti-Cw antibody. On further testing, the donor RBCs were negative for Cw antigen. Conclusion: Antibody screening and identification is recommended in pretransfusion testing, especially in multi-transfused patients and patients belonging to the reproductive age group, so that antibody to low-frequency antigen can be detected and its potential to cause HTR and HDFN can be assessed.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed471    
    Printed16    
    Emailed0    
    PDF Downloaded53    
    Comments [Add]    

Recommend this journal