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CASE REPORT
Year : 2022  |  Volume : 7  |  Issue : 2  |  Page : 205-208

Detection of weak “B” phenotype while resolving an ABO discrepancy: A rare case of B subgroup


1 Indus Hospital Blood Center, The Indus Hospital and Health Network, Karachi, Pakistan
2 Indus Hospital Research Center, The Indus Hospital and Health Network, Karachi, Pakistan
3 Department of Hematology and Blood Centre, The Indus Hospital and Health Network, Karachi, Pakistan

Correspondence Address:
Neelum Mansoor
Department of Hematology and Blood Centre, The Indus Hospital and Health Network, Karachi
Pakistan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/gjtm.gjtm_32_22

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Quantitative and/or qualitative differences in ABO phenotypes give rise to ABO discrepancies causing difficulties in establishing the accurate phenotype. These discrepant serological reactions result in significant delays in blood bank. The correct typing of the blood group is imperative to prevent ABO incompatibility issues. However, the discrepant results encountered in routine settings are a challenge to immunohematologists. The variants of the ABO occur very rarely particularly true for B subgroups. Here, we present a case study of a healthy blood donor, discrepant results in forward and reverse blood grouping led us to perform adsorption-elution test. The presence of anti-B in the eluate confirmed the presence of weaker variant of B antigen on the surface of red blood cells. Correct identification of blood group is mutually important for donor and recipient to prevent the occurrence of any transfusion reaction. The serologically determined weak B phenotypes, however, require further confirmation through genomic analysis.


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